Article

Critical assessment of the ability of Boolean threshold models to describe gene regulatory network dynamics

2025-03-11

Abstract excerpt

The inference of gene regulatory networks (GRNs) from high-throughput data constitutes a fundamental and challenging task in systems biology. Boolean networks are a popular modeling framework to understand the dynamic nature of GRNs. In the absence of reliable methods to infer the regulatory logic of Boolean GRN models, researchers frequently assume threshold logic as a default. Using the largest repository of pub...

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Identifiers and source

Literature Corpus work: 855ba34a-3a90-535a-a3d0-1d64fe068299
DOI: 10.1101/2025.03.06.641948

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