Article

NAD(H)-mediated tetramerization controls the activity of <i>Legionella pneumophila</i> phospholipase PlaB

2020-09-01

Abstract excerpt

The virulence factor and phospholipase PlaB promotes lung colonization, tissue destruction, and intracellular replication of Legionella pneumophila , the causative agent of Legionnaires’ disease. It is exposed at the bacterial surface and shows an extraordinary activation mechanism by tetramer deoligomerization. To unravel the molecular basis for enzyme activation and localization, we determined the crystal struc...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 84869a23-cc57-589e-90a9-29b36a0af07f
DOI: 10.1101/2020.09.01.246603

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

NAD(H)-mediated tetramerization controls the activity of <i>Legionella pneumophila</i> phospholipase PlaBDOI 10.1101/2020.09.01.246603Read

Phospholipase PlaB of Legionella pneumophila Represents a Novel Lipase FamilySemantic proximity Read

Structural basis for substrate recognition by a unique <i>Legionella</i> phosphoinositide phosphataseSemantic proximity Read

Functional diversification despite structural congruence in the HipBST toxin-antitoxin system of <i>Legionella pneumophila</i>Semantic proximity Read

Structural snapshots along the reaction pathway of Yersinia pestis RipA, a putative butyryl-CoA transferase.Semantic proximity Read

Identification and Structural Characterization of a Legionella Phosphoinositide Phosphatase*Semantic proximity Read

A patatin-like phospholipase mediates <i>Rickettsia parkeri</i> escape from host membranesSemantic proximity Read

Solution structure of the phosphatidylinositol 3-phosphate binding domain from the <i>Legionella</i> effector SetASemantic proximity Read

Host FIH-Mediated Asparaginyl Hydroxylation of Translocated Legionella pneumophila Effectors.Semantic proximity Read

Stabilization of glucose-6-phosphate dehydrogenase oligomers enhances catalytic activity and stability of clinical variants.Semantic proximity Read

Supramolecular assembly of the <i>E. coli</i> LdcI upon acid stressSemantic proximity Read

Contribution of N ε -lysine Acetylation towards Regulation of Bacterial PathogenesisSemantic proximity Read

An Atypical α/β-Hydrolase Fold Revealed in the Crystal Structure of Pimeloyl-Acyl Carrier Protein Methyl Esterase BioG from Haemophilus influenzae.Semantic proximity Read