Article

DYNATE: Localizing Rare-Variant Association Regions via Multiple Testing Embedded in an Aggregation Tree

2022-12-02

Abstract excerpt

Rare variants (RVs) genetic association studies enable researchers to uncover the variation in phenotypic traits left unexplained by common variation. Traditional single-variant analysis lacks power; thus, researchers have developed various methods to aggregate the effects of RVs across genomic regions to study their collective impact. Some existing methods utilize a static delineation of genomic regions, often re...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8482a610-a639-55a6-b546-8e9cb913d8dd
DOI: 10.1101/2022.12.01.518706

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

DYNATE: Localizing Rare-Variant Association Regions via Multiple Testing Embedded in an Aggregation TreeDOI 10.1101/2022.12.01.518706Read

DYNATE: Localizing rare-variant association regions via multiple testing embedded in an aggregation tree.Semantic proximity Read

Local Joint Testing Improves Power and Identifies Hidden Heritability in Association Studies.Semantic proximity Read

Multiple-Tissue Integrative Transcriptome-Wide Association Studies Discovered New Genes Associated With Amyotrophic Lateral SclerosisSemantic proximity Read

Rare-variant association studies: When are aggregation tests more powerful than single-variant tests?Semantic proximity Read

Detecting Local Genetic Correlations with Scan StatisticsSemantic proximity Read

Excalibur: A new ensemble method based on an optimal combination of aggregation tests for rare-variant association testing for sequencing data.Semantic proximity Read

DoEstRare: A statistical test to identify local enrichments in rare genomic variants associated with disease.Semantic proximity Read

Regional Collapsing of Rare Variation Implicates Specific Genic Regions in ALSSemantic proximity Read

On the simultaneous association analysis of large genomic regions: a massive multi-locus association test.Semantic proximity Read

Local joint testing improves power and identifies missing heritability in association studiesSemantic proximity Read

AeQTL: eQTL analysis using region-based aggregation of rare genomic variants.Semantic proximity Read

An optimal weighted aggregated association test for identification of rare variants involved in common diseases.Semantic proximity Read