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DYNATE: Localizing rare-variant association regions via multiple testing embedded in an aggregation tree.

Genetic epidemiology - 1 Feb 2024

Li Xuechan, Pura John, Allen Andrew, Owzar Kouros, Lu Jianfeng, Harms Matthew, Xie Jichun

Abstract excerpt

Rare-variants (RVs) genetic association studies enable researchers to uncover the variation in phenotypic traits left unexplained by common variation. Traditional single-variant analysis lacks power; thus, researchers have developed various methods to aggregate the effects of RVs across genomic regions to study their collective impact. Some existing methods utilize a static delineation of genomic regions, often...

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PMID: 38014869
DOI: 10.1002/gepi.22542
PMCID: PMC10842871

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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