Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770.

doi:10.1073/pnas.0904709106

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Article

Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770.

Proceedings of the National Academy of Sciences of the United States of America - 3 Nov 2009

Van Goor Fredrick, Hadida Sabine, Grootenhuis Peter D J, Burton Bill, Cao Dong, Neuberger Tim, Turnbull Amanda, Singh Ashvani, Joubran John, Hazlewood Anna, Zhou Jinglan, McCartney Jason, Arumugam Vijayalaksmi, Decker Caroline, Yang Jennifer, Young Chris, Olson Eric R, Wine Jeffery J, Frizzell Raymond A, Ashlock Melissa, Negulescu Paul

Abstract excerpt

Cystic fibrosis (CF) is a fatal genetic disease caused by mutations in the gene encoding the CF transmembrane conductance regulator (CFTR), a protein kinase A (PKA)-activated epithelial anion channel involved in salt and fluid transport in multiple organs, including the lung. Most CF mutations either reduce the number of CFTR channels at the cell surface (e.g., synthesis or processing mutations) or impair channel...

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PMID: 19846789
DOI: 10.1073/pnas.0904709106
PMCID: PMC2773991

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CFTR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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