Article

The rare DRB1*04-DQ8 haplotype is the main discriminative HLA class II genetic driver of Early-Onset Type 1 Diabetes in the Portuguese population

2023-07-24

Abstract excerpt

<h4>Background</h4> Early-onset Type 1 diabetes (EOT1D) is considered a disease subtype with distinctive immunological and clinical features. While both Human Leukocyte Antigen (HLA) and non-HLA variants contribute to age at T1D diagnosis, detailed analyses of EOT1D-specific genetic determinants are still lacking. This study scrutinized the involvement of the HLA class II locus in EOT1D genetic control. <h4>Method...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8206e566-c42d-5a9a-b32f-ee0b85616faf
DOI: 10.1101/2023.07.23.23293034

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The rare DRB1*04-DQ8 haplotype is the main discriminative HLA class II genetic driver of Early-Onset Type 1 Diabetes in the Portuguese populationDOI 10.1101/2023.07.23.23293034Read

The rare DRB1*04:08-DQ8 haplotype is the main HLA class II genetic driver and discriminative factor of Early-onset Type 1 diabetes in the Portuguese population.Semantic proximity Read

Next-generation sequencing reveals additional HLA class I and class II alleles associated with type 1 diabetes and age at onset.Semantic proximity Read

Association between HLA alleles and haplotypes with age at diagnosis of type 1 diabetes in an admixed Brazilian population: A nationwide study.Semantic proximity Read

Genetics of type 1 diabetesSemantic proximity Read

Type 1 Diabetes Genetic Risk Scores: History, Application and Future Directions.Semantic proximity Read

The Genetic Architecture of Type 1 DiabetesSemantic proximity Read

HLA class II alleles and haplotypes associated with susceptibility to type 1 diabetes and to type 1 diabetes with concomitant autoimmune diseases: a cross-sectional study from Eastern Croatia.Semantic proximity Read

Type 1 Diabetes Genetic Risk Score classifies diabetes subtypes in Indians: Impact of HLA diversity on the lower discriminative abilitySemantic proximity Read

Genetic Epidemiology of Type 1 Diabetes in the 22 Arab Countries.Semantic proximity Read

Characteristics of Type 1 Diabetes Among Patients Carrying the Protective HLA-DQB1*06:02 Allele.Semantic proximity Read

Pathogenesis of type 1 diabetes: lessons from natural history studies of high-risk individuals.Semantic proximity Read

Prevalence, clinical characteristics and HLA genotypes of idiopathic type 1 diabetes: A cross-sectional study.Semantic proximity Read