Article

Cortical surface area drives volumetric and cognitive deficits in complex congenital heart disease

2025-10-10

Abstract excerpt

Individuals with complex congenital heart disease (CHD) are at increased risk for cognitive impairments linked to altered brain structure, including reduced cortical volume. Cortical volume is determined by two distinct morphometric measures: cortical thickness (CT) and surface area (SA), each with unique developmental, genetic, and evolutionary origins. Despite their importance, few studies have examined the diff...

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Literature Corpus work: 81c7e2d1-f721-55da-a783-b05b173078f2
DOI: 10.1101/2025.10.09.25337644

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