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Integrating Machine Learning and Spatial Transcriptomics Uncovers Shared Immunomodulatory Deubiquitinases in MAFLD and HCC

2025-06-29

Abstract excerpt

<title>Abstract</title> <p>Hepatocellular carcinoma (HCC) represents a malignancy with high global mortality. Metabolic dysfunction-associated fatty liver disease (MAFLD) serves as a significant contributory pathogenic factor. Deubiquitinases (DUBs), which regulate protein homeostasis, are implicated in disease progression. This study focused on identifying shared mechanisms between MAFLD and HCC, screening for k...

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Literature Corpus work
819635e0-8543-5bff-ab3b-7ca1c5e12a1a
DOI
10.21203/rs.3.rs-6909459/v1
Open publication

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Integrating Machine Learning and Spatial Transcriptomics Uncovers Shared Immunomodulatory Deubiquitinases in MAFLD and HCCDOI 10.21203/rs.3.rs-6909459/v1
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