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Refractory testicular germ cell tumors are highly sensitive to the targeting of polycomb pathway demethylases KDM6A and KDM6B

2024-10-18

Abstract excerpt

<title>Abstract</title> <p>Testicular germ cell tumors (TGCTs) can be treated with cisplatin-based therapy. However, a clinically significant number of cisplatin-resistant patients die from progressive disease as no effective alternatives exist. Curative cisplatin therapy results in acute and life-long toxicities in the young TGCT patient population providing a rationale to decrease cisplatin exposure. In contras...

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Literature Corpus work
819124f0-fd8d-51b9-bcdd-1cba4304db08
DOI
10.21203/rs.3.rs-4986186/v1
Open publication

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