Article

Phenotype of a transient neonatal diabetes point mutation (SUR1-R1183W) in mice

2021-03-15

Abstract excerpt

<h4>Background: </h4> The K ATP channel plays a key role in glucose homeostasis by coupling metabolically generated changes in ATP to insulin secretion from pancreatic beta-cells. Gain-of-function mutations in either the pore-forming (Kir6.2) or regulatory (SUR1) subunit of this channel are a common cause of transient neonatal diabetes mellitus (TNDM), in which diabetes presents shortly after birth but remits wi...

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Literature Corpus work: 80fd8bbc-6054-5ed4-be12-fc0be4dfcfbd
DOI: 10.12688/wellcomeopenres.15529.2

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