Article
Mutations in ATP-sensitive K+ channel genes cause transient neonatal diabetes and permanent diabetes in childhood or adulthood.
Diabetes - 1 Jul 2007
Flanagan Sarah E, Patch Ann-Marie, Mackay Deborah J G, Edghill Emma L, Gloyn Anna L, Robinson David, Shield Julian P H, Temple Karen, Ellard Sian, Hattersley Andrew T
Abstract excerpt
Transient neonatal diabetes mellitus (TNDM) is diagnosed in the first 6 months of life, with remission in infancy or early childhood. For approximately 50% of patients, their diabetes will relapse in later life. The majority of cases result from anomalies of the imprinted region on chromosome 6q24, and 14 patients with ATP-sensitive K+ channel (K(ATP) channel) gene mutations have been reported. We determined the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.