Back to search

Article

Spatial transcriptome sequencing revealed spatial trajectory in the Non-Small Cell Lung Carcinoma

2021-04-26

Abstract excerpt

<h4>ABSTRACT</h4> Deepening understanding in the heterogeneity of tumors is critical for clinical treatment. Here we investigate tissue-wide gene expression heterogeneity throughout a multifocal lung cancer using the spatial transcriptomics (ST) technology. We identified gene expression gradients in stroma adjacent to tumor regions that allow for re-understanding of the tumor micro-environment. The establishment...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
805f1bb9-8a7d-58fe-8e03-c03d43eba85a
DOI
10.1101/2021.04.26.441394
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Spatial transcriptome sequencing revealed spatial trajectory in the Non-Small Cell Lung CarcinomaDOI 10.1101/2021.04.26.441394
Spatial transcriptomics uncovers immune-cell plasticity and dedifferentiation signatures in aggressive lung adenocarcinoma subtypesSemantic proximity
Spatial Transcriptome‐Wide Profiling of Small Cell Lung Cancer Reveals Intra‐Tumoral Molecular and Subtype HeterogeneitySemantic proximity
Technique integration of single-cell RNA sequencing with spatially resolved transcriptomics in the tumor microenvironmentSemantic proximity
Spatial Transcriptomics Reveals Spatially Diverse Cancer-Associated Fibroblast in Lung Squamous Cell Carcinoma Linked to Tumor ProgressionSemantic proximity
Resolving the Spatial and Cellular Architecture of Lung Adenocarcinoma by Multiregion Single-Cell SequencingSemantic proximity
Charting the transcriptomic landscape of primary and metastatic cancers in relation to their origin and target normal tissuesSemantic proximity
Single-Cell Transcriptomic Analyses of Tumor Ecosystems and Spatial Architectures in Human Small Cell Lung CancerSemantic proximity
Combining spatial transcriptomics and ECM imaging in 3D for mapping cellular interactions in the tumor microenvironmentSemantic proximity
Spatiotemporal Profiling Unveiling the Cellular Organization Patterns and Local Protumoral Immune Microenvironment Remodeling in Early Lung Adenocarcinoma ProgressionSemantic proximity
Spatial RNA sequencing methods show high resolution of single cell in cancer metastasis and the formation of tumor microenvironmentSemantic proximity
Beyond Histology: A Unified Transcriptomic Atlas Defines Lung Cancer Biologic States and SubtypesSemantic proximity
Spatial resolution of transcriptomic plasticity states underpinning lethal morphologies in lung adenocarcinomaSemantic proximity
Select a neighboring publication to make it the new centre.