Article

Inhibition of fibrosis with multi-agent therapy in pulmonary fibrosis: Results of a drug library screening

2020-06-29

Abstract excerpt

<h4>Aims</h4> Successful management of IPF will likely require multi-drug therapy as its pathogenesis is thought to be both driven by both pro-inflammatory and pro-fibrotic pathways. We hypothesized that the available anti-fibrotic agents, pirfenidone and nintedanib, may exhibit synergy in suppressing lung fibroblast extracellular matrix protein generation when administered in combination with other orally active...

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Literature Corpus work: 80449557-7f48-5186-8f6d-1509abec646e
DOI: 10.1101/2020.06.29.178061

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