Article
Human herpesvirus 8+ polyclonal IgMλ B-cell lymphocytosis mimicking plasmablastic leukemia/lymphoma in HIV-infected patients.
European journal of haematology - 1 Dec 2013
Oksenhendler Eric, Boutboul David, Beldjord Kheira, Meignin Véronique, de Labarthe Adrienne, Fieschi Claire, Dossier Antoine, Agbalika Felix, Parravicini Carlo, Tosato Giovanna, Gérard Laurence, Galicier Lionel
Abstract excerpt
PURPOSE: Multicentric Castleman disease (MCD) is a distinct lymphoproliferative disorder characterized by inflammatory symptoms, lymphadenopathy, splenomegaly, and cytopenia. Kaposi's sarcoma-associated herpesvirus (KSHV), also called human herpesvirus-8 (HHV-8), is the cause of virtually all cases of MCD occurring in patients with HIV infection. MCD lesions characteristically contain HHV-8-infected polyclonal...
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