Personalized bacteriophage therapy to treat pandrug-resistant spinal P. aeruginosa infection

Abstract excerpt

<title>Abstract</title> <p>A pandrug-resistant <italic>P. aeruginosa</italic> spinal abscess was treated with surgery and personalized phage therapy that was added to cefiderocol and colistin. After a 2-stage approach, despite bacterial persistence with expression of small colony variants, the patient cured with local and intravenous injections of purified bacteriophages as part of the treatment.</p>

Topics

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• Bacteriophages and microbial interactions
• Biofilms
• CRISPR and Genetic Engineering
• Mutation
• Mycobacterium research and diagnosis
• Phenotype
• Plankton
• Pseudomonas aeruginosa

Identifiers and source

Literature Corpus work

7fe6c69a-b518-5888-98ab-0a168a75025b

DOI

10.21203/rs.3.rs-1231457/v1