Evaluating Spike Antigenicity across Endemic Human Coronavirus Models using Flow Virometry

Abstract excerpt

<h4>SUMMARY</h4> While SARS-CoV-2 research has advanced rapidly since COVID-19, endemic human coronaviruses (HCoVs) remain comparatively understudied. Tools to phenotype spike (S), the primary antigenic target on coronaviruses, at the single-virion level could improve vaccine design by capturing variation in epitope availability and spike abundance. Here, we establish a calibrated flow virometry (FV) platform to...

Topics

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• Animal Virus Infections Studies
• Monoclonal and Polyclonal Antibodies Research
• Protein purification and stability
• Respiratory viral infections research
• SARS-CoV-2 and COVID-19 Research
• Viral gastroenteritis research and epidemiology
• Viral Infections and Vectors
• Virus-based gene therapy research

Identifiers and source

Literature Corpus work

7fe5194e-0606-5a3e-8460-16cdbf75efd6

DOI

10.64898/2026.05.28.728498