Article

A novel <i>KCNJ16</i> kidney organoid model recapitulates the disease phenotype and shows restoration of lipid accumulation upon treatment with statins

2023-12-23

Abstract excerpt

<h4>Background</h4> the KCNJ16 gene has been associated with a novel kidney tubulopathy phenotype, viz. disturbed acid-base homeostasis, hypokalemia and altered renal salt transport. KCNJ16 encodes for Kir5.1, which together with Kir4.1 constitutes a potassium channel located at kidney tubular cell basolateral membranes. Preclinical studies provided mechanistical links between Kir5.1 and a disease phenotype, h...

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Literature Corpus work: 7f8adb63-5570-5ea3-8ff4-d9ac3a9000d9
DOI: 10.1101/2023.12.22.572750

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