Article

Spatial Analysis of T Cell Clonality in Autoimmune Kidney Disease Using TRV Probes

2025-09-03

Abstract excerpt

Hypothesizing that the localization of T cell clones correlates with immune function, our goal was to develop an unbiased method to study the spatial distribution of T cells in tissues. We created an in situ hybridization panel with 248 probes that identify immune and tissue cell types, and 132 probes for all variable TRAV, TRBV, TRGV, and TRDV gene segments. Applying this approach to analyze renal biopsies from...

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Identifiers and source

Literature Corpus work: 7f47bc21-f299-5880-b273-4302f88c1cae
DOI: 10.1101/2025.08.29.673064

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