Article
Immune Repertoire Profiling Reveals that Clonally Expanded B and T Cells Infiltrating Diseased Human Kidneys Can Also Be Tracked in Blood.
PloS one - 1 Jan 2015
Weinberger Johannes, Jimenez-Heredia Raul, Schaller Susanne, Suessner Susanne, Sunzenauer Judith, Reindl-Schwaighofer Roman, Weiss Richard, Winkler Stephan, Gabriel Christian, Danzer Martin, Oberbauer Rainer
Abstract excerpt
Recent advances in high-throughput sequencing allow for the competitive analysis of the human B and T cell immune repertoire. In this study we compared Immunoglobulin and T cell receptor repertoires of lymphocytes found in kidney and blood samples of 10 patients with various renal diseases based on next-generation sequencing data. We used Biomed-2 primer panels and ImmunExplorer software to sequence, analyze and...
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