Hyperuricemia and Diabetic Kidney Disease: A Mechanistic Exploration and Clinical Translation Study Based on Multi-Omics Integration and Real-World Evidence

Abstract excerpt

<title>Abstract</title> <p>Background Diabetic kidney disease (DKD), a severe microvascular complication of diabetes. Emerging evidence implicates hyperuricemia (HUA) as a critical yet underexplored contributor to DKD pathogenesis. Methods This study integrates cross-sectional data from the National Health and Nutrition Examination Survey (NHANES), transcriptomic analysis from the Gene Expression Omnibus (GEO) da...

Topics

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• Albuminuria
• Allopurinol
• ATP Binding Cassette Transporter, Subfamily G, Member 2
• Diabetic Nephropathies
• Glucose Transport Proteins, Facilitative
• Hyperuricemia
• Renal Insufficiency, Chronic
• Uric Acid

Identifiers and source

Literature Corpus work

7ee62308-3673-5f7d-8e89-9598a625be97

DOI

10.21203/rs.3.rs-8127837/v1