Article

Relative contribution of gonads and sex chromosomes to sex differences in cell-type gene expression in the mouse medial septum and sex-biased disease risk

2025-12-11

Abstract excerpt

<h4>Background</h4> While sex differences in the brain have traditionally been attributed to gonadal hormones, emerging evidence points to regulation by sex chromosomes. This study aims to differentiate the influence of gonads versus sex chromosomes on cellular gene expression in the mouse medial septum (MS), a critically understudied brain region. <h4>Methods</h4> Using single nucleus RNA-sequencing and the Sex...

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Literature Corpus work: 7eabf639-b272-5344-99bb-9b3b106834bd
DOI: 10.64898/2025.12.08.693050

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