Article

Did variants in inborn errors of immunity genes contribute to the extinction of Neanderthals?

2022-10-20

Abstract excerpt

Neanderthals were a species of archaic human that became extinct around 40,000 years ago. Modern humans have inherited 1-6% of Neanderthal DNA as a result of interbreeding with the Neanderthals. These inherited Neanderthal genes have paradoxical influences, while some can provide protection to viral infections, some others are associated with autoimmune/auto-inflammatory diseases. We hypothesized that genetic vari...

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Literature Corpus work: 7ea1f4f6-6521-5ee0-9388-6b71c462ca7e
DOI: 10.1101/2022.10.19.512108

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