Article

Dissecting and directing pathology foundation models

2026-06-16

Abstract excerpt

Foundation models (FMs) are central to digital pathology, encoding histology images into dense embeddings for facilitating diagnostic classification, molecular alteration prediction, and clinical outcome modeling. However, the opacity of these embeddings renders FM-based systems “black boxes,” limiting their trustworthiness for clinical translation and utility for scientific discovery. Here, we introduce PICASSO...

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Literature Corpus work: 7e9f6232-efc6-5a0a-a09a-0666f5aa192e
DOI: 10.64898/2026.06.12.731496

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