Article

Hydroxychloroquine Synergizes With The PI3K Inhibitor BKM120 to Exhibit Antitumor Efficacy Independent of Autophagy

2021-07-13

Abstract excerpt

<h4>Background: </h4> The critical role of phosphoinositide 3-kinase (PI3K) activation in tumor cell biology has prompted massive efforts to develop PI3K inhibitors (PI3Kis) for cancer therapy. However, recent results from clinical trials have shown only a modest therapeutic efficacy of single-agent PI3Kis in solid tumors. Targeting autophagy has controversial context-dependent effects in cancer treatment. As a FD...

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Literature Corpus work: 7e7d1b09-4e87-5fc7-b08e-52688f4c5d11
DOI: 10.21203/rs.3.rs-691658/v1

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