Article

CLN5 and CLN3 function as a complex to regulate endolysosome function

2020-12-24

Abstract excerpt

CLN5 is a soluble endolysosomal protein whose function is poorly understood. Mutations in this protein cause a rare neurodegenerative disease, Neuronal Ceroid Lipofuscinosis. We previously found that depletion of CLN5 leads to dysfunctional retromer, resulting in the degradation of the lysosomal sorting receptor, sortilin. However, how a soluble lysosomal protein can modulate the function of a cytosolic protein, r...

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Literature Corpus work: 7e5c81cc-4816-57d6-b58a-62d7f1cc4556
DOI: 10.1101/2020.12.24.423824

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