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Article

Neuronal ceroid lipofuscinoses are connected at molecular level: interaction of CLN5 protein with CLN2 and CLN3.

Molecular biology of the cell - 1 Jul 2002

Vesa Jouni, Chin Mark H, Oelgeschläger Kathrin, Isosomppi Juha, DellAngelica Esteban C, Jalanko Anu, Peltonen Leena

Abstract excerpt

Neuronal ceroid lipofuscinoses (NCLs) are neurodegenerative storage diseases characterized by mental retardation, visual failure, and brain atrophy as well as accumulation of storage material in multiple cell types. The diseases are caused by mutations in the ubiquitously expressed genes, of which six are known. Herein, we report that three NCL disease forms with similar tissue pathology are connected at the...

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Identifiers

PMID: 12134079
DOI: 10.1091/mbc.e02-01-0031
PMCID: PMC117323

Genes

CLN5
CLN3
NCL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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