Article

Proteome-Wide Assessment of Clustering of Missense Variants in Neurodevelopmental Disorders Versus Cancer

2024-02-04

Abstract excerpt

<h4>ABSTRACT</h4> Missense de novo variants (DNVs) and missense somatic variants contribute to neurodevelopmental disorders (NDDs) and cancer, respectively. Proteins with statistical enrichment based on analyses of these variants exhibit convergence in the differing NDD and cancer phenotypes. Herein, the question of why some of the same proteins are identified in both phenotypes is examined through investigation o...

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Literature Corpus work: 7e4fcd44-0a5d-5b45-bf11-5bb0f7c53bcb
DOI: 10.1101/2024.02.02.24302238

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