Article

Endosomal dysfunction contributes to cerebellar deficits in spinocerebellar ataxia type 6

2023-06-26

Abstract excerpt

Spinocerebellar ataxia type 6 (SCA6) is a rare disease that is characterized by cerebellar dysfunction. Patients have progressive motor coordination impairment, and postmortem brain tissue reveals degeneration of cerebellar Purkinje cells and a reduced level of cerebellar brain-derived neurotrophic factor (BDNF). However, the pathophysiological changes underlying SCA6 are not fully understood. We carried out RNA s...

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Literature Corpus work: 7dbf6fa4-13db-5f34-86ae-3147756e4c1c
DOI: 10.1101/2023.06.26.546542

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