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Article

Exploring uncatalogued genetic variation in antimicrobial resistance gene families in Escherichia coli: an observational analysis.

The Lancet. Microbe - 1 Nov 2024

Lipworth Samuel, Crook Derrick, Walker A Sarah, Peto Tim, Stoesser Nicole

Abstract excerpt

BACKGROUND: Antimicrobial resistance (AMR) in Escherichia coli is a global problem associated with substantial morbidity and mortality. AMR-associated genes are typically annotated based on similarity to variants in a curated reference database, with the implicit assumption that uncatalogued genetic variation within these is phenotypically unimportant. In this study, we evaluated the performance of the AMRFinder...

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PMID: 39378891
DOI: 10.1016/S2666-5247(24)00152-6
PMCID: PMC7617469

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