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Article

Novel Computational Protocols for Functionally Classifying and Characterising Serine Beta-Lactamases

22 Jun 2016

Abstract excerpt

Beta-lactamases represent the main bacterial mechanism of resistance to beta-lactam antibiotics and are a significant challenge to modern medicine. We have developed an automated classification and analysis protocol that exploits structure- and sequence-based approaches and which allows us to propose a grouping of serine beta-lactamases that more consistently captures and rationalizes the existing three...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 27332861
DOI: 10.1371/journal.pcbi.1004926

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