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Quantitative proteomic analysis based on tandem mass tagging (TMT) reveals key proteins related to DNA hydroxymethylation enzyme TET1 for spermatogonia self-renewal

2022-10-24

Abstract excerpt

<h4>Background: </h4> Abnormal spermatogonia (SSCs) can cause spermatogenic disorders such as weak spermatozoa, oligospermia, and azoospermia. DNA hydroxymethylase TET1 hydroxylates the methylation sites of specific genes, enabling the process of DNA demethylation and regulating gene expression. However, the key differential genes affected by the specific action of TET1 and the mechanism of interaction between the...

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Literature Corpus work: 7d917b2f-5b08-5232-a26d-06510837d8cb
DOI: 10.21203/rs.3.rs-2149016/v1

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