Article

The COVID-19 antibody responses, isotypes and glycosylation: Why SARS-CoV-2 Spike protein complex binding of IgG3 is potentiated in some and immuno-pathologies manifest

2023-01-13

Abstract excerpt

COVID-19 syndrome does not occur in all who are infected with SARS-CoV-2, and symptoms vary. The anti-SARS CoV-2 Spike immune responses is confounded by the Spike proteins ability to bind Igγ3 heavy chains. This appears to be via sialic acid glycans found on the O-Linked glycosylation moieties of this heavy chain extended neck domain. Furthermore glycosylation of light chains, particularly Kappa (κ), is an associa...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7d47e2c7-03b8-5986-919b-1eab31c7e4f8
DOI: 10.1101/2023.01.13.23284524

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The COVID-19 antibody responses, isotypes and glycosylation: Why SARS-CoV-2 Spike protein complex binding of IgG3 is potentiated in some and immuno-pathologies manifestDOI 10.1101/2023.01.13.23284524Read

SARS-CoV2 Envelop Proteins Reshape the Serological Responses of COVID-19 PatientsSemantic proximity Read

SARS-CoV2 envelop proteins reshape the serological responses of COVID-19 patientsSemantic proximity Read

Immunoglobulin G1 Fc glycosylation as an early hallmark of severe COVID-19Semantic proximity Read

Afucosylated immunoglobulin G responses are a hallmark of enveloped virus infections and show an exacerbated phenotype in COVID-19Semantic proximity Read

Spike antibodies targeting GRP78 predispose to cardiovascular complications compared to DengueSemantic proximity Read

Spike N354 glycosylation augments SARS-CoV-2 fitness for human adaptation through multiple mechanismsSemantic proximity Read

Profile of Immunoglobulin G N-Glycome in COVID-19 Patients: A Case-Control Study.Semantic proximity Read

Spike N354 glycosylation augments SARS-CoV-2 fitness for human adaptation through structural plasticitySemantic proximity Read

Differential patterns of cross-reactive antibody response against SARS-CoV-2 spike protein detected for chronically ill and healthy COVID-19 naïve individualsSemantic proximity Read

Glycans of SARS-CoV-2 Spike Protein in Virus Infection and Antibody ProductionSemantic proximity Read

Common determinants of severe Covid-19 infection are explicable by SARS-CoV-2 secreted glycoprotein interaction with the CD33-related Siglecs, Siglec-3 and Siglec-5/14.Semantic proximity Read

Emerging COVID-19 coronavirus: glycan shield and structure prediction of spike glycoprotein and its interaction with human CD26Semantic proximity Read