Article

Alpha kinase 3 signaling at the M-band maintains sarcomere integrity and proteostasis in striated muscle

2022-09-03

Abstract excerpt

<h4>SUMMARY</h4> Pathogenic variants in alpha kinase 3 ( ALPK3 ) cause cardiomyopathy and musculoskeletal disease. How ALPK3 mutations result in disease remains unclear because little is known about this atypical kinase. Using a suite of engineered human pluripotent stem cells (hPSCs) we show that ALPK3 localizes to the M-Band of the sarcomere. ALPK3 deficiency disrupted sarcomeric organization and calcium kin...

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Literature Corpus work: 7d468fde-6a35-53d6-8cca-3f11205b40b4
DOI: 10.1101/2022.09.01.506029

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