Article

A p53-ΔNp73 signaling axis drives selective motor neuron degeneration in spinal muscular atrophy

2026-06-25

Abstract excerpt

Selective neuronal vulnerability is a hallmark of many neurodegenerative diseases, yet how ubiquitous genetic insults cause highly selective neuronal loss remains poorly understood. In spinal muscular atrophy (SMA), reduced SMN levels trigger degeneration of specific motor neuron pools. Although non-apoptotic, p53-mediated death pathways have been implicated, p53 is expressed in both vulnerable and resistant neuro...

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Literature Corpus work: 7cb74916-c790-5725-a5cb-019d71873f9f
DOI: 10.64898/2026.06.20.733537

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