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Article

Abolishing Trp53-dependent apoptosis does not benefit spinal muscular atrophy model mice.

European journal of human genetics : EJHG - 1 Mar 2006

Tsai Ming Shiun, Chiu Yung Tsung, Wang Sue Hong, Hsieh-Li Hsiu Mei, Li Hung

Abstract excerpt

Spinal muscular atrophy (SMA) is the most common genetic motoneuron degenerative disorder, but the mechanism(s) of motoneuron death is unclear. Previously, a direct interaction between tumor-suppressive TP53 protein and the SMA determinant gene product, survival motor neuron protein, was identified and therefore it has been suggested that a mechanism of TP53-dependent apoptosis plays an important role in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16391561
DOI: 10.1038/sj.ejhg.5201556

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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