Back to search

Article

N-acetyl cysteine: A tool to perturb SARS-CoV-2 spike protein conformation

2021-01-05

Abstract excerpt

The infection caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) resulted in a pandemic with huge death toll and economic consequences. The virus attaches itself to the human epithelial cells through noncovalent bonding of its spike protein with the angiotensin-converting enzyme-2 (ACE2) receptor on the host cell. We hypothesized that perturbing the functionally active conformation of spik...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
7c50ed28-2ac0-57ea-862a-586bf0dc669e
DOI
10.26434/chemrxiv.12687923.v2
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 8 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
N-acetyl cysteine: A tool to perturb SARS-CoV-2 spike protein conformationDOI 10.26434/chemrxiv.12687923.v2
The combination of Bromelain and Acetylcysteine (BromAc) synergistically inactivates SARS-CoV-2Semantic proximity
Mutating novel interaction sites in NRP1 reduces SARS-CoV-2 spike protein internalizationSemantic proximity
Thiol drugs decrease SARS-CoV-2 lung injury <i>in vivo</i> and disrupt SARS-CoV-2 spike complex binding to ACE2 <i>in vitro</i>Semantic proximity
Structure-function relations of the SARS-CoV-2 spike protein and impact of mutations in the variants of concern.Semantic proximity
SARS-CoV-2: phylogenetic status, mutations and therapeutic research based on spike protein.Semantic proximity
The SARS-CoV-2 Spike Glycoprotein as a Drug and Vaccine Target: Structural Insights into Its Complexes with ACE2 and AntibodiesSemantic proximity
Comprehensive Structural and Molecular Comparison of Spike Proteins of SARS-CoV-2, SARS-CoV and MERS-CoV, and Their Interactions with ACE2Semantic proximity
Investigation of Critical Binding Pattern in SARS-CoV-2 Spike Glycoprotein with Angiotensin-Converting Enzyme 2: An in Silico Analysis&nbsp;Semantic proximity
Select a neighboring publication to make it the new centre.