Article

Thiol drugs decrease SARS-CoV-2 lung injury <i>in vivo</i> and disrupt SARS-CoV-2 spike complex binding to ACE2 <i>in vitro</i>

2020-12-08

Abstract excerpt

Neutrophil-induced oxidative stress is a mechanism of lung injury in COVID-19, and drugs with a functional thiol group (“thiol drugs”), especially cysteamine, have anti-oxidant and anti-inflammatory properties that could limit this injury. Thiol drugs may also alter the redox status of the cysteine-rich SARS-CoV-2 spike glycoprotein (SARS-2-S) and thereby disrupt ACE2 binding. Using ACE2 binding assay, reporter vi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8a3c2dc2-e948-56ae-b303-ab61ecdb6570
DOI: 10.1101/2020.12.08.415505

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Thiol drugs decrease SARS-CoV-2 lung injury <i>in vivo</i> and disrupt SARS-CoV-2 spike complex binding to ACE2 <i>in vitro</i>DOI 10.1101/2020.12.08.415505Read

Elucidation of the antiviral mechanism of cystine and theanine through transcriptome analysis of mice and comparison with COVID-19 gene set dataSemantic proximity Read

CNP blocks mitochondrial depolarization and inhibits SARS-CoV-2 replication <i>in vitro</i> and <i>in vivo</i>Semantic proximity Read

The combination of Bromelain and Acetylcysteine (BromAc) synergistically inactivates SARS-CoV-2Semantic proximity Read

Pathogenesis-based pre-exposure prophylaxis associated with low risk of SARS-CoV-2 infection in healthcare workers at a designated Covid-19 hospitalSemantic proximity Read

Inhalable nanocatchers for SARS-CoV-2 inhibitionSemantic proximity Read

Methylene Blue Is a Nonspecific Protein-Protein Interaction Inhibitor with Potential for Repurposing as an Antiviral for COVID-19Semantic proximity Read

Vulnerabilities of the SARS-CoV-2 Virus to Proteotoxicity—Opportunity for Repurposed Chemotherapy of COVID-19 InfectionSemantic proximity Read

<i>In Vitro</i> Activity of Cysteamine Against SARS-CoV-2 VariantsSemantic proximity Read

N-acetylcysteine - A Convenient Rationale for COVID-19Semantic proximity Read

Inhalation of ACE2-expressing lung exosomes provides prophylactic protection against SARS-CoV-2Semantic proximity Read

Cold atmospheric plasma for preventing infection of viruses that use ACE2 for entrySemantic proximity Read

Allicin inhibits SARS-CoV-2 replication and abrogates the antiviral host response in the Calu-3 proteomeSemantic proximity Read