Article

Mutating novel interaction sites in NRP1 reduces SARS-CoV-2 spike protein internalization

2021-10-12

Abstract excerpt

The global pandemic of Coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2 has become a severe global health problem because of its rapid spread( 1 ). Both angiotensin-converting enzyme 2 and neuropilin 1 provide initial viral binding sites for SARS-CoV-2 ( 2, 3 ). Here, we show that three cysteine residues located in a1/a2 and b1 domains of neuropilin 1 are necessary for SARS-CoV-...

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Literature Corpus work: 1f33ff21-9a83-59fe-80eb-9f9b14b2043e
DOI: 10.1101/2021.10.11.463689

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