Article
Within-family validation of a new polygenic predictor of general cognitive ability
2025-12-11
Abstract excerpt
<p>We present a polygenic score (PGS) for general cognitive ability (GCA) that demonstrates a substantial increase in predictive accuracy both among unrelated individuals and within-families relative to existing predictors. In the UK Biobank (UKB), our PGS achieves a standardized regression coefficient with fluid intelligence of β=0.406 (SE 0.009), corresponding to an R² of 16.4% (95% confidence interval: [15.1%,...
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Identifiers and source
- Literature Corpus work
- 7bcfcecf-7557-582a-bf2a-19f1f0cd72ba
- DOI
- 10.31234/osf.io/jfhtu_v2