Article

Hydralazine inhibits cysteamine dioxygenase to treat preeclampsia and senesce glioblastoma

2024-12-21

Abstract excerpt

The vasodilator hydralazine (HYZ) has been used clinically for ∼ 70 years and remains on the World Health Organization’s List of Essential Medicines as a therapy for preeclampsia. Despite its longstanding use and the concomitant progress toward a general understanding of vasodilation, the target and mechanism of HYZ have remained unknown. We show that HYZ selectively targets 2-aminoethanethiol dioxygenase (ADO) by...

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Literature Corpus work: 7b89d58a-a1d4-5dea-abf1-62bdd8ad4f38
DOI: 10.1101/2024.12.19.629450

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