Article

<i>Promfusion</i> : a synthetic fusion promoter enabling enhanced and balanced photoreceptor transgene expression

2026-06-09

Abstract excerpt

Achieving efficient and balanced transgene expression in both rods and cones remains a major challenge in retinal gene therapy. Current promoters either lack specificity or fail to provide sufficient cellular coverage and expression level. To address this limitation, we developed and evaluated two fusion promoters, Pikali and Nocchu, by combining PR1.7, a cone-specific promoter and GRK1, a promoter most active in...

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Literature Corpus work: 7b7009e0-b26f-53e3-b060-559e7c8e3c64
DOI: 10.64898/2026.06.05.730342

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