Article

The SF3B1 inhibitor pladienolide B massively inhibits DNA damage signaling and repair and counteracts resistance to platinum salts in Non-Small Cell Lung Cancer

2026-02-19

Abstract excerpt

<h4>Background</h4> Lung cancer, including Non-Small Cell Lung Carcinoma (NSCLC), is the leading cause of cancer mortality worldwide. Platinum salts are the gold standard chemotherapy for NSCLC but many patients develop resistance leading to disease progression. Identifying new therapeutic strategies to counteract resistance is crucial. Pharmacological compounds targeting core components of the spliceosome machin...

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Literature Corpus work: 7b542858-1029-55aa-91c7-c92edecb13a9
DOI: 10.64898/2026.02.17.706284

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