Article

Low CDKN1B expression accompanied by reduced tumor-infiltrating lymphocytes is correlated with an adverse prognosis in breast cancer: machine learning analysis and drug discovery

2023-08-29

Abstract excerpt

The cyclin-dependent kinase inhibitor 1B (CDKN1B) gene encodes the p27Kip1 protein, which plays an important role in cell cycle regulation and cell proliferation, and its role in breast cancer prognosis is controversial. The aim of this study was to analyze the clinicopathological parameters, molecular interactions, and anticancer immune responses in patients with CDKN1B expression. We investigated the clinicopath...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7aa58368-d42c-52f4-98dd-f2dc3e39ab08
DOI: 10.21203/rs.3.rs-3282839/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Low CDKN1B expression accompanied by reduced tumor-infiltrating lymphocytes is correlated with an adverse prognosis in breast cancer: machine learning analysis and drug discoveryDOI 10.21203/rs.3.rs-3282839/v1Read

Cyclin B1: A potential prognostic and immunological biomarker in pan-cancerSemantic proximity Read

Prognostic model based on six PD-1 expression and immune infiltration-associated genes predicts survival in breast cancerSemantic proximity Read

Cyclin-Dependent Kinase Inhibitors Function as Potential Immune Regulators via Inducing Pyroptosis in Triple Negative Breast CancerSemantic proximity Read

Systematic Identification of the Cancer Pathways and Molecules Related With Breast Cancer ImmunogenicitySemantic proximity Read

Deciphering molecular landscape of breast cancer progression and insights from functional genomics and therapeutic explorations followed by in vitro validationSemantic proximity Read

Bioinformatics analysis reveling prognostic roles of CDK1 in breast cancerSemantic proximity Read

Identification of a DNA Methylation-Driven Genes-Based Prognostic Model and Drug Targets in Breast Cancer: In silico Screening of Therapeutic Compounds and in vitro Characterization.Semantic proximity Read

Comprehensive molecular profiling of the B7 family of immune-regulatory ligands in breast cancerSemantic proximity Read

PD-1 and PD-L1 correlated gene expression profiles and their association with clinical outcomes of breast cancerSemantic proximity Read

ADRB1 was identified as a potential biomarker for breast cancer by the co-analysis of tumor mutational burden and immune infiltration.Semantic proximity Read

Comprehensive analysis reveals a prognostic and therapeutic biomarker CD3D in the breast carcinoma microenvironmentSemantic proximity Read

CDK1, CCNB1, and CCNB2 are Prognostic Biomarkers and Correlated with Immune Infiltration in Hepatocellular CarcinomaSemantic proximity Read