Back to search

Article

Noninvasive diagnosis of secondary infections in COVID-19 by sequencing of plasma microbial cell-free DNA

2022-09-10

Abstract excerpt

<h4>Background</h4> Secondary infection (SI) diagnosis in COVID-19 is challenging, due to overlapping clinical presentations, practical limitations in obtaining samples from the lower respiratory tract (LRT), and low sensitivity of microbiologic cultures. <h4>Research Question</h4> Can metagenomic sequencing of plasma microbial cell-free DNA (mcfDNA-Seq) help diagnose SIs complicating COVID-19? <h4>Study Design an...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
7a6b7016-5ff9-5522-a2b9-eef510a68625
DOI
10.1101/2022.09.09.22279790
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Noninvasive diagnosis of secondary infections in COVID-19 by sequencing of plasma microbial cell-free DNADOI 10.1101/2022.09.09.22279790
Plasma microbial cell-free DNA load is associated with mortality in patients with COVID-19Semantic proximity
Metagenomic next-generation sequencing Reveals Respiratory Pathogen distribution in COVID-19Semantic proximity
Plasma Microbial Cell-free DNA Sequencing from Over 15,000 Patients Identified a Broad Spectrum of PathogensSemantic proximity
Metagenomic next-generation sequencing Reveals Respiratory flora distribution in COVID-19Semantic proximity
Clinical Impact of Metagenomic Next-Generation Sequencing of Plasma Cell-Free DNA for the Diagnosis of Infectious Diseases: A Multicenter Retrospective Cohort StudySemantic proximity
Clinical Impact of Metagenomic Next-Generation Sequencing of Plasma Cell-Free DNA for the Diagnosis of Infectious Diseases: A Multicenter Retrospective Cohort StudySemantic proximity
Comprehensive evaluation of plasma microbial cell-free DNA sequencing for predicting bloodstream and local infections in clinical practice: a multicenter retrospective studySemantic proximity
Clinical Utility of Plasma Microbial Cell-Free DNA Sequencing Among Immunocompromised Patients With PneumoniaSemantic proximity
Microbial signatures in the lower airways of mechanically ventilated COVID19 patients associated with poor clinical outcomeSemantic proximity
Comparing the diagnostic value of targeted with metagenomic next-generation sequencing in immunocompromised patients with lower respiratory tract infectionSemantic proximity
Illuminating the Challenges and Diagnostic Utility of Plasma Microbial Cell-Free DNA Sequencing in Suspected Infective Endocarditis: A Retrospective Observational Cohort StudySemantic proximity
Microbial signatures in the lower airways of mechanically ventilated COVID19 patients associated with poor clinical outcomeSemantic proximity
Select a neighboring publication to make it the new centre.