Article

Mifepristone as a pharmacological intervention for stress-Induced alcohol craving: a translational crossover randomized trial

2023-01-04

Abstract excerpt

Preclinical and clinical work suggests that mifepristone (glucocorticoid receptor antagonist), may be a viable treatment for alcohol use disorder (AUD). The aim of this work was to translate our preclinical mifepristone study using yohimbine (α2 receptor antagonist) stress-induced reinstatement of alcohol-seeking to a clinical setting. This was a Phase 1/2, outpatient, cross-over, randomized, double-blind, placebo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7a405a9c-07b6-5872-8e0c-50d4e8208e90
DOI: 10.1101/2023.01.02.23284122

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mifepristone as a pharmacological intervention for stress-Induced alcohol craving: a translational crossover randomized trialDOI 10.1101/2023.01.02.23284122Read

Stress-induced and cue-induced craving for alcohol in heavy drinkers: Preliminary evidence of genetic moderation by the OPRM1 and CRH-BP genes.Semantic proximity Read

Pharmacotherapy for alcohol dependence: A stratified approach.Semantic proximity Read

Defining the role of corticotropin releasing factor binding protein in alcohol consumptionSemantic proximity Read

A prospective study of genetic factors, human laboratory phenotypes, and heavy drinking in late adolescence.Semantic proximity Read

Hormone circuit analysis explains why most HPA drugs fail for mood disorders and predicts the few that workSemantic proximity Read

Genetic modulation of plasma NPY stress response is suppressed in substance abuse: association with clinical outcomes.Semantic proximity Read

A Methodological Checklist for fMRI Drug Cue Reactivity Studies: Development and Expert ConsensusSemantic proximity Read

Hormonal contraception and SSRI’s influence on oxytocin and cortisol reactivity to stress in patients with borderline personality disorderSemantic proximity Read

Pilot study suggests DNA methylation of the glucocorticoid receptor gene (NR3C1) is associated with MDMA-assisted therapy treatment response for severe PTSDSemantic proximity Read

A Translational Model of Compulsive Alcohol Use in HumansSemantic proximity Read

Machine Learning-Driven fMRI Analysis for Objective Craving PredictionSemantic proximity Read

The FDA-approved drug apremilast suppresses alcohol intake: clinical and pre-clinical validationSemantic proximity Read