Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Review article: inhibition of methanogenic archaea by statins as a targeted management strategy for constipation and related disorders

11 Nov 2015

Abstract excerpt

BACKGROUND: Observational studies show a strong association between delayed intestinal transit and the production of methane. Experimental data suggest a direct inhibitory activity of methane on the colonic and ileal smooth muscle and a possible role for methane as a gasotransmitter. Archaea are the only confirmed biological sources of methane in nature and Methanobrevibacter smithii is the predominant methanogen...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gastrointestinal motility and disorders
Share to Gut microbiota and health
Share to Probiotics and Fermented Foods

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26559904
DOI: 10.1111/apt.13469

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Review article: inhibition of methanogenic archaea by statins as a targeted management strategy for constipation and related disordersPMID 26559904Read ↗

Lovastatin lactone may improve irritable bowel syndrome with constipation (IBS-C) by inhibiting enzymes in the archaeal methanogenesis pathwaySemantic proximity Read ↗

Reduced B12 Uptake and Increased Gastrointestinal Formate Drive Archaeome-Mediated Breath Methane Emission in HumansSemantic proximity Read ↗

The Role of Methanogenic Archaea in Inflammatory Bowel Disease—A ReviewSemantic proximity Read ↗

The Roles of Phytogenic Feed Additives on Mitigating Ruminant Methane EmissionSemantic proximity Read ↗

Methane emission of humans is explained by dietary habits, host genetics, local formate availability and a uniform archaeomeSemantic proximity Read ↗

Archaea and the human gut: New beginning of an old storySemantic proximity Read ↗

Genomic insights into adaptations of TMA-utilizing methanogens to diverse habitats including the human gutSemantic proximity Read ↗

Assessing the colonic microbiome, hydrogenogenic and hydrogenotrophic genes, transit and breath methane in constipationSemantic proximity Read ↗

Methane Trajectory Phenotypes on Glucose Breath Testing Are Associated With Slow Colonic Transit: A Group-Based Trajectory Modeling Analysis.Semantic proximity Read ↗

New Insight Into Rumen Methanogen Function: a Barrier Blocking Trimethylamine From Entering the Host BodySemantic proximity Read ↗

Relations between transit time, fermentation products, and hydrogen consuming flora in healthy humans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.