Article

Discovering and targeting dynamic drugging pockets of the oncogene KRAS-G12D

2022-07-02

Abstract excerpt

Activated KRAS-G12D mutations are the one of most frequent oncogenic drivers in human cancers. Unfortunately, no therapeutic agent directly targeting KRAS-G12D has been clinically approved yet, with such mutated species remaining undrugged. Notably, cofactor Mg 2+ is closely related to the function of small GTPases, but no investigation has been done yet on Mg 2+ when associated with KRAS. Herein, through micros...

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Literature Corpus work: 79a53ee9-8432-5075-b81b-a44aa6a8b8df
DOI: 10.1101/2022.07.01.498403

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