Article

Measles fusion complexes from central nervous system clinical isolates: decreased interaction between hemagglutinin and fusion proteins

2021-06-19

Abstract excerpt

Measles virus (MeV) viral entry is mediated by a fusion complex comprised of a receptor binding protein (hemagglutinin, H) and a fusion protein (F). The wild type H/F complex requires interaction with specific proteinaceous receptors (CD150/SLAM and nectin-4) in order to be activated. In contrast the H/F complexes isolated from viruses infecting the central nervous system (CNS) do not require a specific receptor....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7890db40-18dc-535c-ab2e-28f237e5378d
DOI: 10.1101/2021.06.18.449082

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Measles fusion complexes from central nervous system clinical isolates: decreased interaction between hemagglutinin and fusion proteinsDOI 10.1101/2021.06.18.449082Read

Measles Fusion Machinery Is Dysregulated in Neuropathogenic VariantsSemantic proximity Read

Molecular Features of the Measles Virus Viral Fusion Complex That Favor Infection and Spread in the BrainSemantic proximity Read

The Measles Virus Hemagglutinin β-Propeller Head β4-β5 Hydrophobic Groove Governs Functional Interactions with Nectin-4 and CD46 but Not Those with the Signaling Lymphocytic Activation MoleculeSemantic proximity Read

Cell-to-Cell Measles Virus Spread between Human Neurons Is Dependent on Hemagglutinin and Hyperfusogenic Fusion ProteinSemantic proximity Read

The measles virus matrix F50S mutation from a lethal case of subacute sclerosing panencephalitis promotes receptor-independent neuronal spread.Semantic proximity Read

Fitness selection of hyperfusogenic measles virus F proteins associated with neuropathogenic phenotypesSemantic proximity Read

Mutations in the stalk of the measles virus hemagglutinin protein decrease fusion but do not interfere with virus-specific interaction with the homologous fusion protein.Semantic proximity Read

Mutations in the Fusion Protein of Measles Virus That Confer Resistance to the Membrane Fusion Inhibitors Carbobenzoxy-d-Phe-l-Phe-Gly and 4-Nitro-2-Phenylacetyl Amino-Benzamide.Semantic proximity Read

Selectively Receptor-Blind Measles Viruses: Identification of Residues Necessary for SLAM- or CD46-Induced Fusion and Their Localization on a New Hemagglutinin Structural ModelSemantic proximity Read

Altered Interaction of the Matrix Protein with the Cytoplasmic Tail of Hemagglutinin Modulates Measles Virus Growth by Affecting Virus Assembly and Cell-Cell FusionSemantic proximity Read

Measles Virus Mutants Possessing the Fusion Protein with Enhanced Fusion Activity Spread Effectively in Neuronal Cells, but Not in Other Cells, without Causing Strong CytopathologySemantic proximity Read

Structural and Mechanistic Studies of Measles Virus Illuminate Paramyxovirus EntrySemantic proximity Read