Article

<i>In vitro</i> selection of cyclized, glycosylated peptide antigens that tightly bind HIV high mannose patch antibodies

2025-03-28

Abstract excerpt

In vitro selection is typically limited to discovery of peptides, proteins and nucleic acids. Given the importance of carbohydrate-protein interactions in diverse areas of biology including cell adhesion/recognition, immunoregulation and host-pathogen interactions, directed-evolution-based methods for discovery of potent glycoligands are greatly needed. We have previously reported a method for in vitro selection...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 77d05039-099b-5fa2-9571-abe19be56267
DOI: 10.1101/2025.03.24.645033

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>In vitro</i> selection of cyclized, glycosylated peptide antigens that tightly bind HIV high mannose patch antibodiesDOI 10.1101/2025.03.24.645033Read

Recent strategies targeting HIV glycans in vaccine designSemantic proximity Read

Non-Carbohydrate Inhibitors of Sialic Acid-binding Immunomodulatory-type Lectin-7 (Siglec-7) Discovered from Genetically Encoded Bicyclic Peptide LibrariesSemantic proximity Read

Interrogation of side chain biases for oligomannose recognition by antibody 2G12 via structure-guided phage display libraries.Semantic proximity Read

Directed Evolution of 2G12‐Targeted Nonamannose Glycoclusters by SELMASemantic proximity Read

Constrained Combinatorial Libraries of Gp2 Proteins Enhance Discovery of PD-L1 Binders.Semantic proximity Read

In vitro nanobody discovery for integral membrane protein targetsSemantic proximity Read

Synthetic Glycomacromolecules of Defined Valency, Absolute Configuration, and Topology Distinguish between Human LectinsSemantic proximity Read

DNA Encoded Glycan Libraries as a next-generation tool for the study of glycan-protein interactionsSemantic proximity Read

Isolation of Chemically Cyclized Peptide Binders Using Yeast Surface DisplaySemantic proximity Read

Antibody 2G12 recognizes di-mannose equivalently in domain- and nondomain-exchanged forms but only binds the HIV-1 glycan shield if domain exchanged.Semantic proximity Read

Enhancing ML-based binder design with high-throughput screening: a comparison of mRNA and yeast display technologiesSemantic proximity Read

Molecular Profile of an Antibody Response to HIV-1 as Probed by Combinatorial LibrariesSemantic proximity Read