Article

Design and Synthesis of Potent First-in-Class Histones Acetyltransferase Modulators

2025-03-05

Abstract excerpt

<h4>ABSTRACT</h4> Epigenetic regulation governs gene expression through histone modifications, particularly the acetylation of lysine residues. These modifications are orchestrated by enzymes such as histone acetyltransferases (HATs) and histone deacetylases (HDACs). Among them, p300 plays a critical role in various disorders such as neurodegenerative conditions (i.e. Alzheimer’s disease, and Alzheimer’s Disease...

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Literature Corpus work: 777d58ed-0289-57c2-b18c-f02615e1ce96
DOI: 10.1101/2025.03.03.641271

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